Nearly 40 million Americans have symptoms of upper respiratory allergies, making antihistamines among the most frequently used pharmacologic agents. Although there are mediators of allergic symptoms in addition to histamine, therapy for allergic rhinitis and urticaria has focused upon the use of antihistamines. The classic histamine H1-receptor antagonists, however, are not selective for the H1 site and produce a variety of dopaminergic, serotonergic, and cholinergic responses leading to considerable adverse effects in the central nervous system consequent to both their pharmacologic nonselectivity and their ability to penetrate the blood-brain barrier readily. The second-generation antihistamines were a major advance in the therapy of allergic rhinitis, because they do not penetrate the blood-brain barrier as rapidly and are also designed for greater specificity at H1-receptor.
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A group of experts has examined the properties of desloratadine and verified their adherence to the criteria based on high-level evidence.
Publications resulting from an exhaustive bibliographical search were analysed for the methodology and level of evidence of the studies. Desloratadine pharmacodynamics, pharmacokinetics, efficacy and safety profiles perfectly meet the criteria defined by the EAACI and ARIA for oral H1 antihistamines for the treatment of allergic rhinitis.
The issues highlighted by this critical analysis are common to all H1 antihistamines of the second generation. Journal page Archives Contents list.
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Les urticaires constituent leur indication de choix. Histamine is an inflammation mediator that is fundamental for the development of some allergic reactions and is also implied in several common dermatological affections. Anti-H1s are molecules capable of couteracting the effect of histamine on its specific receptors. There are two types: first generation anti-H1 and second generation anti-H1. A reference search was made using the Pubmed data bank. Critical analysis was made of the articles selected based on their evidence. Demonstration of the efficacy of anti-H1 was only confirmed in a few dermatitis.
Clinical Comparison of Histamine H1-receptor Antagonist Drugs