La vacuna DTaP es muy segura y eficaz para prevenir la difteria. Las vacunas, al igual que cualquier otro medicamento, pueden tener efectos secundarios. Los efectos secundarios que pueden producirse son generalmente leves y pueden incluir lo siguiente:. La difteria es una enfermedad grave causada por una toxina veneno producida por bacterias.

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Background : New vaccination strategies are needed to control the increasing problem of pertussis in teenagers and adults. Aim: To determine the immunogenicity and reactogenicity of a diphtheria-tetanus-acellular pertussis dTpa vaccine with reduced antigen content. Material and Methods: A single dose of the dTpa vaccine was administered to 60 children 10 to 11 years old and 60 healthy adults.

At the moment of vaccination and one month later, antibody levels were measured against 3 B pertussis antigens: anti-pertussis toxin PT , anti-pertactin PRN and anti-filamentous hemagglutinin FHA , as well as anti-tetanus and anti-diphtheria antibodies. Local and general symptoms were registered during 14 days following vaccine administration. Geometric mean titers GMT significantly increased in adults and children.

The seroprotection level achieved for tetanus and diphtheria antibodies one month after vaccination was No serious adverse events were reported during the study. Recibido el 28 de agosto, Trabajo financiado por Laboratorio GlaxoSmithKline. Laboratorio Glaxo SmithKline. Estudio abierto con un solo grupo. Todos los participantes recibieron una dosis de la misma vacuna. Todos los sujetos fueron analizables para reactogenicidad.

Anticuerpos anti pertussis. Pertussis vaccine. WB Saunders Co 3rd Ed ; Pertussis vaccination: Use of acellular pertussis vaccines among infants and young children. Recommendations of the ACIP. Return of epidemic pertussis in the United States. Pediatr Infect Dis J ; Reemergence of pertussis in the highly vaccinated population of the Netherlands: Observations on surveillance data. Emerging Infectious Diseases ; 6: Outcomes of Bordetella pertussis infection in different age groups of an immunized population.

J Infect Dis ; La Tos Ferina en Chile. Linnemann CC, Nasenbeny J. Pertussis in the adult. Ann Rev Med ; Pertussis in adults. Am J Dis Child ; Jenkinson D. Duration of effectiveness of pertussis vaccine: evidence from a 10 years community study. Br Med ; Pertussis in adults: frequency of transmission after household exposure. Lancet ; Outbreak of pertussis in highly immunized adolescents and its secondary spread to their families. Acta Pediatrica Japonica ; Household contact study of Bordetella pertussis infections.

Clin Infect Dis ; Intrafamiliar spread of pertussis. J Ped ; Nelson JD. The changing epidemiology of pertussis in young infants. The role of adults as reservoirs of infection. Black S. Epidemiology of pertussis. Pediatr Infect Dis J ; S Centers for Disease Control. Pertussis Surveillance: United States, MMWR ; Trollfors B, Rabo E. Whooping cough in adults. British Med Journal ; Symptoms and complications of pertussis in adults.

Infection ; Outbreak of pertussis in a fully immunized adolescent and adult population. Arch Ped Adolesc Med ; A search for Bordetella pertussis infection in university students. Pertussis in german adults. Pertussis in adolescents and adults: time to reimmunize? Semin Resp Infect ; Diphteria, tetanus and pertussis: recommendations for vaccine use and other preventive measures. A controlled trial of two acellular vaccines and one whole-cell vaccine against pertussis.

N Engl J Med ; A controlled trial of a two-component acellular, a five component acellular, and a whole-cell pertussis vaccine. Pichichero ME. Acellular pertussis vaccines: Towards an improved safety profile. Drug Safety ; Randomized controlled trial of two component, three component and five component acellular pertussis vaccines compared with whole cell pertussis vaccine. Comparative safety and immunigenicity of an acellular versus whole cell pertussis component of diphteria-tetanus- pertussis vaccines in Senegalese infants.

Efficacy of acellular pertussis vaccine in infants after household exposure. JAMA ; Adult formulation of five component acellular pertussis vaccine combined with diphteria and tetanus toxoids and inactivated poliovirus vaccine is safe and immunogenic in adolescents and adults.

A randomized controlled trial with a diphteria-tetanus-acellular pertussis dTpa vaccine in adults. Vaccine ; A randomized trial of two acellular pertussis vaccines dTpa and pa and a licensed diptheria-tetanus vaccine Td in adults.

A search for serologic correlates of immunity to Bordetella pertussis cough illnesses. Levels of anti-pertussis antibodies over time related to protection after household exposure to Bordetella pertussis.

Reactogenicity and immunogenicity of reduced antigen content diphteria, tetanus and acellular pertussis vaccines as a booster in years old children primed with diftheria, tetanus and whole cell before 2 years of age. Katia Abarca. Fax Servicios Personalizados Revista.

Immunogenicity and reactogenicity of a reduced antigen content diphteria- tetanus-acellular pertussis vaccine dTpa in 10 to 11 years old children and in adults Background : New vaccination strategies are needed to control the increasing problem of pertussis in teenagers and adults.

Immunogenicity and reactogenicity of a reduced antigen content diphteria- tetanus-acellular pertussis vaccine dTpa in 10 to 11 years old children and in adults.


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