Metrics details. Sex chromosomal abnormalities are relatively common, yet many aspects of these syndromes remain unexplored. For instance epidemiological data in 47,XYY persons are still limited. Using a national Danish registry, we identified persons with 47,XYY or a compatible karyotype, whereof 36 were deceased; all were diagnosed from to We report nationwide prevalence data, data regarding age at diagnosis, as well as total and cause specific mortality data in these persons.
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XYY syndrome is a genetic condition found in males only. About 1 in 1, boys have it. Other symptoms can include problems with spoken language and processing spoken words, coordination problems, weaker muscles, hand tremors, and behavioral difficulties. Most boys with XYY syndrome can grow up healthy, have normal sexual development and fertility, and lead productive lives. Symptoms can vary greatly among boys. Depending on which symptoms a boy has and how severe they are, doctors may recommend various treatments.
Boys who have XYY syndrome are born with it. It's called XYY because they have an extra Y chromosome in most or all of their cells. Usually, a person has 46 chromosomes in each cell, divided into 23 pairs, which includes two sex chromosomes. Half of the chromosomes are inherited from the father and the other half from the mother. The chromosomes contain genes, which determine an individual's characteristics, such as eye color and height.
XYY syndrome is not caused by anything the parents did or did not do. The disorder is a random error in cell division. This error can happen before conception in the reproductive cells of the mother or the father, or early in the embryo's development. When the extra chromosome is the result of incorrect cell division early in the embryo's development, a boy may have a mosaic form of XYY syndrome. This means some of the cells have an extra Y chromosome, but not all do. Boys with mosaic XYY syndrome usually have fewer symptoms.
Noticeable signs and symptoms of XYY syndrome can vary greatly. Some boys have no obvious signs, while others have mild symptoms.
Occasionally, the disorder causes significant problems. Boys with XYY syndrome may have some or all of these physical symptoms to some degree:. Some boys also may have delayed development of their social, language, and learning skills. They also can have problems with reading and understanding math, and may have mild delays with coordination. Some boys with XYY syndrome may develop behavioral problems, such as ADHD , autism, explosive temper, impulsivity, or defiant behavior.
These problems might ease as they get older and reach adulthood. Otherwise, treatment can help manage them. A small number of boys may have increased testicular size for their age, or have an increased risk for asthma and seizures.
Many boys with XYY syndrome are healthy and have no obvious symptoms. So sometimes the condition isn't diagnosed or is only found while a doctor checks for a different issue. XYY syndrome often is found because parents talked with a doctor about concerns with their son's development. This can help boys receive a diagnosis early. Research has shown that early interventions and treatments are more effective. To diagnosis XYY syndrome, a blood sample is checked for the presence of the extra Y chromosome.
Before birth, the condition can be found through a chromosomal analysis. Testing is done on the fluid surrounding the fetus, tissue from the placenta, or the blood from the mother. There's no cure for XYY syndrome, but there are treatment options that can help address specific symptoms.
Finding services early is important and can greatly increase their ability to help your son live a healthier, more productive life.
Options vary greatly depending on how old a boy is at the time of his diagnosis, whether he has noticeable symptoms, and the severity of those symptoms. Regular doctor visits. At periodic visits, a doctor can monitor a boy's development for delays, social and language disabilities, or health problems and treat these promptly.
Educational support services. Educational support can teach boys ways to keep pace in school. Some might be eligible for an individualized educational program IEP or education plan , which are designed to help children with specialized needs. Early intervention services. It can be very helpful and often more effective for a boy to have speech , occupational , physical , or developmental therapy in the early months of life or as soon as concerns are identified.
Speech therapy and physical therapy can improve your son's speaking, reading, and writing skills and help increase strength and coordination.
Occupational therapy and behavioral therapy can help your son develop more confidence and interact better with other children. The whole family can benefit from counseling to better understand XYY syndrome and help a boy who has it to live a productive life. Early inventions should be considered at infancy for physical therapy, at 15 months for speech delay, at 1st grade for reading and learning issues, and at 3rd grade for anxiety or depression.
Boys with XYY syndrome can develop speech, learning, or social challenges at a young age. This can make them more likely to have low self-esteem and lead to school or social problems. If your son is having trouble making friends or struggles in school, talk to your doctor or the principal or school counselor. Counseling and therapy can teach your son practical skills to help him make friends and feel more confident in school, and educational services can help your son succeed academically.
It's important to speak to your doctor if you have any concerns about your son's physical and emotional development. Note: All information is for educational purposes only. For specific medical advice, diagnoses, and treatment, consult your doctor.
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This table lists symptoms that people with this disease may have. For most diseases, symptoms will vary from person to person. People with the same disease may not have all the symptoms listed. The HPO collects information on symptoms that have been described in medical resources. The HPO is updated regularly. Support and advocacy groups can help you connect with other patients and families, and they can provide valuable services. Many develop patient-centered information and are the driving force behind research for better treatments and possible cures.
XYY syndrome is a genetic condition found in males only. About 1 in 1, boys have it. Other symptoms can include problems with spoken language and processing spoken words, coordination problems, weaker muscles, hand tremors, and behavioral difficulties. Most boys with XYY syndrome can grow up healthy, have normal sexual development and fertility, and lead productive lives. Symptoms can vary greatly among boys. Depending on which symptoms a boy has and how severe they are, doctors may recommend various treatments. Boys who have XYY syndrome are born with it.
Although many males with this condition are taller than average, the chromosomal change sometimes causes no unusual physical features. Most males with 47,XYY syndrome have normal production of the male sex hormone testosterone and normal sexual development, and they are usually able to father children. Affected boys can have delayed development of motor skills such as sitting and walking or weak muscle tone hypotonia. Other signs and symptoms of this condition include hand tremors or other involuntary movements motor tics , seizures, and asthma. Males with 47,XYY syndrome have an increased risk of behavioral, social, and emotional difficulties compared with their unaffected peers. Physical features related to 47,XYY syndrome can include increased belly fat, a large head macrocephaly , unusually large teeth macrodontia , flat feet pes planus , fifth fingers that curve inward clinodactyly , widely spaced eyes ocular hypertelorism , and abnormal side-to-side curvature of the spine scoliosis.